KMID : 1161420180210060551
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Journal of Medicinal Food 2018 Volume.21 No. 6 p.551 ~ p.559
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Quercetin Reduces Tumor Necrosis Factor Alpha-Induced Muscle Atrophy by Upregulation of Heme Oxygenase-1
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Kim Ye-Ji
Kim Chu-Sook Joe Yeon-Soo Chung Hun-Taeg Ha Tae-Youl Yu Ri-Na
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Abstract
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The inflammatory cytokine tumor necrosis factor ¥á (TNF¥á), upregulated in the obese condition, promotes protein degradation and is implicated in obesity-related skeletal muscle atrophy and age-related sarcopenia. Quercetin, a flavonoid, elicits antioxidative and anti-inflammatory activities. In this study, we investigated the effect of quercetin on TNF¥á-induced skeletal muscle atrophy as well as its potential mechanism of action. In this study, we observed that quercetin suppressed expression of TNF¥á-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes. The HO-1 inhibitor ZnPP suppressed the inhibitory actions of quercetin on TNF¥á-induced atrophic responses and degradation of I¥êB-¥á in myotubes. Moreover, quercetin supplementation to high-fat diet-fed obese mice inhibited obesity-induced atrophic responses in skeletal muscle, accompanied by upregulation of HO-1 and inactivation of nuclear factor-kappa B (NF-¥êB), and the quercetin actions were attenuated in Nrf2-deficient mice. These findings suggest that quercetin protects against TNF¥á-induced muscle atrophy under obese conditions through Nrf2-mediated HO-1 induction accompanied by inactivation of NF-¥êB. Quercetin may be used as a dietary supplement to protect against obesity-induced skeletal muscle atrophy.
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KEYWORD
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inflammation, muscle atrophy, obesity, quercetin
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